Inhibition of peptidoglycan synthesis by the antibiotic diumycin A.
نویسندگان
چکیده
Diumycin A, a new antibiotic, was found to inhibit cell wall synthesis by Staphylococcus aureus, a phenomenon accompanied by accumulation of uridine-5'-diphosphate-N-acetyl-muramyl-pentapeptide. The antibiotic inhibited in vitro peptidoglycan synthesis by particulate preparations of Bacillus stearothermophilus and Escherichia coli by preventing the utilization of N-acetyl-glucosamine-N-acetyl-muramyl-pentapeptide. In contrast to vancomycin, the antibiotics diumycin, prasinomycin, moenomycin, 11.837 RP, and enduracidin do not inhibit particulate d-alanine carboxypeptidase.
منابع مشابه
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عنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 2 6 شماره
صفحات -
تاریخ انتشار 1972